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The antibody against NKRF was raised in rabbit using the Human NKRF as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against NKRF was raised in rabbit using the Human NKRF as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-47807A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NKRF |
| Target Synonyms | NKRF antibody; ITBA4 antibody; NRF antibody; NF-kappa-B-repressing factor antibody; NFkB-repressing factor antibody; Protein ITBA4 antibody; Transcription factor NRF antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Human NKRF | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O15226 |
Uniprot Id
O15226
Target Species
Human
Target Name
NKRF
Target Full Name
NF-kappa-B-repressing factor
Target Function
Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
Target Subcellular Location
Nucleus, nucleolus.
Target Tissue Specificity
Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
Target Research Area
Cell Biology
Target Synonyms
NKRF; ITBA4; NRF; NF-kappa-B-repressing factor; NFkB-repressing factor; Protein ITBA4; Transcription factor NRF
Target Background
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants.
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