Rabbit anti-Human NLGN3 Polyclonal Antibody

Uniprot Id

Q9NZ94

Target Species

Human

Target Name

NLGN3

Target Full Name

Neuroligin-3

Target Function

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.

Target Involvement

Autism, X-linked 1 (AUTSX1); Asperger syndrome, X-linked, 1 (ASPGX1)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.

Target Protein Families

Type-B carboxylesterase/lipase family

Target Tissue Specificity

Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.

Target Synonyms

Gliotactin homolog; HNL3; Neuroligin-3; Nlgn3; NLGN3_HUMAN

Target Background

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.