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Rabbit anti-Human NLRP4 Polyclonal Antibody

The antibody against NLRP4 was raised in rabbit using the Synthetic peptide of Human NLRP4 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.

ADC-26319A

The antibody against NLRP4 was raised in rabbit using the Synthetic peptide of Human NLRP4 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.

$299.00

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Specifications


Cat.No ADC-26319A ClonalityPolyclonal
Host SpeciesRabbitTarget NameNLRP4
Target SynonymsCancer/testis antigen 58 antibody; CLR19.5 antibody; CT58 antibody; FLJ32126 antibody; NACHT, leucine rich repeat and PYD containing 4 antibody; NACHT, LRR and PYD containing protein 4 antibody; NACHT, LRR and PYD domains-containing protein 4 antibody; NALP4_HUMAN antibody; NLR family, pyrin domain containing 4 antibody; NLRP4 antibody; Nucleotide binding oligomerization domainFormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer0.05% NaN3, 40% Glycerol., pH7.4 PBSPurification MethodAntigen affinity purified
ConjugateNon-conjugatedApplicationELISA, IHC
StorageUpon receipt

Immunogen Information


Immunogen DescriptionSynthetic peptide of Human NLRP4Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ96MN2
Background Information
  • Uniprot Id

    Q96MN2

  • Target Species

    Human

  • Target Name

    NLRP4

  • Target Full Name

    NACHT, LRR and PYD domains-containing protein 4

  • Target Function

    May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

  • Target Protein Families

    NLRP family

  • Target Synonyms

    Cancer/testis antigen 58; CLR19.5; CT58; FLJ32126; NACHT, leucine rich repeat and PYD containing 4; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NALP4_HUMAN; NLR family, pyrin domain containing 4; NLRP4; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT containing protein 2; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN containing APAF1 like protein 4; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2; RNH2

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