Rabbit anti-Human NLRP7 Polyclonal Antibody

Uniprot Id

Q8WX94

Target Species

Human

Target Name

NLRP7

Target Full Name

NACHT, LRR and PYD domains-containing protein 7

Target Function

Inhibits CASP1/caspase-1-dependent IL1B secretion.

Target Involvement

Hydatidiform mole, recurrent, 1 (HYDM1)

Target Protein Families

NLRP family

Target Tissue Specificity

Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.

Target Synonyms

CLR19.4; FLJ94610; HYDM; MGC126470; MGC126471; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains containing protein 7; NACHT, LRR and PYD domains-containing protein 7; NALP7; NALP7_HUMAN; NLR family, pyrin domain containing 7; NLRP7; NOD12; Nucleotide-binding oligomerization domain protein 12; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; PYRIN-containing APAF1-like protein 3

Target Background

This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.