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The antibody against NLRP9 was raised in rabbit using the Synthetic peptide of Human NLRP9 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against NLRP9 was raised in rabbit using the Synthetic peptide of Human NLRP9 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26276A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NLRP9 |
| Target Synonyms | LRR and PYD domains-containing protein 9 antibody; NALP9_HUMAN antibody; NLRP9 antibody; Nucleotide-binding oligomerization domain protein 6 antibody; PYRIN and NACHT-containing protein 12 antibody, NACHT | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human NLRP9 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7RTR0 |
Uniprot Id
Q7RTR0
Target Species
Human
Target Name
NLRP9
Target Full Name
NACHT, LRR and PYD domains-containing protein 9
Target Function
As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.
Target Subcellular Location
Cytoplasm. Inflammasome.
Target Protein Families
NLRP family
Target Tissue Specificity
Expressed in ileum intestinal epithelial cells. Not detected in peripheral blood mononuclear cells. Expressed in cerebral endothelial cells and, at much lower levels, in brain pericytes.
Target Synonyms
NACHT, LRR and PYD domains-containing protein 9; NALP9_HUMAN; NLRP9; Nucleotide-binding oligomerization domain protein 6; PYRIN and NACHT-containing protein 12
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