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The antibody against NMRAL1 was raised in rabbit using the Recombinant Human NmrA-like family domain-containing protein 1 protein (1-299AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against NMRAL1 was raised in rabbit using the Recombinant Human NmrA-like family domain-containing protein 1 protein (1-299AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
| Cat.No | ADC-24251A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NMRAL1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human NmrA-like family domain-containing protein 1 protein (1-299AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HBL8 |
Uniprot Id
Q9HBL8
Target Species
Human
Target Name
NMRAL1
Target Full Name
NmrA-like family domain-containing protein 1
Target Function
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
Target Protein Families
NmrA-type oxidoreductase family
Target Synonyms
FLJ25918 ; HSCARG; NmrA like family domain containing 1; NmrA like family domain containing protein 1; NmrA-like family domain-containing protein 1; NMRAL1; NMRL1_HUMAN; SDR48A1
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