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The antibody against NOB1 was raised in rabbit using the Recombinant Human RNA-binding protein NOB1 protein (103-229AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against NOB1 was raised in rabbit using the Recombinant Human RNA-binding protein NOB1 protein (103-229AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-11484A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NOB1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | FITC conjugated |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human RNA-binding protein NOB1 protein (103-229AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9ULX3 |
Uniprot Id
Q9ULX3
Target Species
Human
Target Name
NOB1
Target Full Name
RNA-binding protein NOB1
Target Function
May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Target Subcellular Location
Nucleus.
Target Protein Families
NOB1 family
Target Tissue Specificity
Detected in liver, lung, placenta, endothelial cells and spleen.
Target Synonyms
Adenocarcinoma antigen recognized by T lymphocytes 4 ; ART 4; ART4; MST158; MSTP158; Nin one binding protein ; NIN1/PSMD8 binding protein 1 homolog; NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); nob1; NOB1_HUMAN; NOB1P; Phosphorylation regulatory protein HP-10; Protein ART-4; Protein ART4; PSMD8 binding protein 1 ; PSMD8BP1; RNA binding protein NOB1; RNA-binding protein NOB1
Target Background
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).
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