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The antibody against NOTUM was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human NOTUM (NP_848588.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NOTUM was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human NOTUM (NP_848588.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00179A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NOTUM |
| Target Synonyms | hNOTUM; NOTUM | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BxPC-3, HepG2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human NOTUM (NP_848588.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6P988 | Immunogen Sequence |
Uniprot Id
Q6P988
Target Species
Human
Target Name
NOTUM
Target Full Name
Palmitoleoyl-protein carboxylesterase NOTUM
Target Function
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Target Subcellular Location
Secreted.
Target Protein Families
Pectinacetylesterase family, Notum subfamily
Target Tissue Specificity
Rarely expressed in adult normal tissues.
Target Research Area
Neuroscience
Target Synonyms
NOTUM; notum pectinacetylesterase homolog (Drosophila) ; Notum pectinacetylesterase homolog; NOTUM_HUMAN; Protein notum homolog
Target Background
Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region.
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