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Rabbit anti-Human NPFF Polyclonal Antibody

The antibody against NPFF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02740A

The antibody against NPFF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-02740A ClonalityPolyclonal
Host SpeciesRabbitTarget NameNPFF
Target SynonymsFMRFAL; NPFFFormLiquid
Species ReactivityHuman, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesRat plasmaApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 34-113 of human NPFF (NP_003708.1).Target SpeciesHuman
Immunogen SequenceAEEDSEPLPPQDAQTSGSLLHYLLQAMERPGRSQAFLFQPQRFGRNTQGSWRNEWLSPRAGEGLNSQFWSLAAPQRFGKKUniprot IDO15130
Background Information
  • Uniprot Id

    O15130

  • Target Species

    Human

  • Target Name

    NPFF

  • Target Full Name

    Pro-FMRFamide-related neuropeptide FF

  • Target Function

    Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.

  • Target Subcellular Location

    Secreted.

  • Target Protein Families

    FARP (FMRFamide related peptide) family

  • Target Research Area

    Neuroscience

  • Target Synonyms

    NPFF; Pro-FMRFamide-related neuropeptide FF; FMRFamide-related peptides) [Cleaved into: Neuropeptide SF; NPSF); Neuropeptide FF; NPFF); Neuropeptide AF; NPAF)]

  • Target Background

    This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

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