Rabbit anti-Human NPL Polyclonal Antibody

Uniprot Id

Q9BXD5

Target Species

Human

Target Name

NPL

Target Full Name

N-acetylneuraminate lyase

Target Function

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Experiments show the true substrate is aceneuramate (linearized Neu5Ac).

Target Subcellular Location

Cytoplasm.

Target Protein Families

DapA family, NanA subfamily

Target Tissue Specificity

Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.

Target Synonyms

0610033B02Rik; C112; C1orf13; Dihydrodipicolinate synthase; Dihydrodipicolinate synthetase homolog 1; MGC149582; MGC61869; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NAL; NALase; NPL; NPL_HUMAN; NPL1; RP11-249O6.1; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyase

Target Background

This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.