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The antibody against NPRL3 was raised in rabbit using the Recombinant Human GATOR complex protein NPRL3 protein (349-482AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against NPRL3 was raised in rabbit using the Recombinant Human GATOR complex protein NPRL3 protein (349-482AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-03311A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NPRL3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human GATOR complex protein NPRL3 protein (349-482AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q12980 |
Uniprot Id
Q12980
Target Species
Human
Target Name
NPRL3
Target Full Name
GATOR1 complex protein NPRL3
Target Function
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Target Involvement
Epilepsy, familial focal, with variable foci 3 (FFEVF3)
Target Subcellular Location
Lysosome membrane.
Target Protein Families
NPR3 family
Target Tissue Specificity
Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes.
Target Synonyms
4 gene protein; Alpha-globin regulatory element-containing gene protein; C16ORF35; CGTHBA; Conserved gene telomeric to alpha globin cluster; HS 40; MARE; Nitrogen permease regulator 3-like protein; Nitrogen permease regulator-like 3 (S. cerevisiae); NPR3; NPRL3; NPRL3_HUMAN; Protein CGTHBA; RMD11
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