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The antibody against NRBF2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human NRBF2 (NP_110386.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against NRBF2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human NRBF2 (NP_110386.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-13364A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NRBF2 |
| Target Synonyms | COPR; COPR1; COPR2; NRBF-2; F2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2 | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human NRBF2 (NP_110386.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96F24 | Immunogen Sequence |
Uniprot Id
Q96F24
Target Species
Human
Target Name
NRBF2
Target Full Name
Nuclear receptor-binding factor 2
Target Function
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).; Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation.
Target Subcellular Location
Nucleus. Cytoplasm. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome.
Target Tissue Specificity
Detected in keratinocytes, liver and placenta. Expressed in a subset of cells in pediatric medulloblastoma.
Target Synonyms
Comodulator of PPAR and RXR 1; Comodulator of PPAR and RXR 2; Comodulator of PPAR and RXR; COPR; COPR1; COPR2; DKFZp564C1664; FLJ30395; NRBF 2 ; NRBF-2; NRBF2; NRBF2_HUMAN; Nuclear receptor binding factor 2; Nuclear receptor-binding factor 2
Target Background
Involved in autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III.
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