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The antibody against NRG4 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRG4 (NP_612640.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against NRG4 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRG4 (NP_612640.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-04318A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NRG4 |
| Target Synonyms | HRG4; NRG4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat lung | Application | ELISA, WB, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRG4 (NP_612640.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | RKGHFQRASSVQ | Uniprot ID | Q8WWG1 |
Uniprot Id
Q8WWG1
Target Species
Human
Target Name
NRG4
Target Full Name
Pro-neuregulin-4, membrane-bound isoform
Target Function
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Target Subcellular Location
[Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-4]: Secreted.
Target Protein Families
Neuregulin family
Target Synonyms
DKFZp779N0541; DKFZp779N1944; Heregulin 4; HRG4; Neuregulin 4; Neuregulin-4; NRG-4; NRG4; NRG4_HUMAN; pro-neuregulin-4; membrane-bound isoform; Pro-NRG4
Target Background
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).
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