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The antibody against NRIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 939-1158 of human NRIP1 (NP_003480.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NRIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 939-1158 of human NRIP1 (NP_003480.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10859A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NRIP1 |
| Target Synonyms | CAKUT3; RIP140; NRIP1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 939-1158 of human NRIP1 (NP_003480.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P48552 | Immunogen Sequence |
Uniprot Id
P48552
Target Species
Human
Target Name
NRIP1
Target Full Name
Nuclear receptor-interacting protein 1
Target Function
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
Target Subcellular Location
Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
Target Synonyms
NRIP 1; NRIP1; NRIP1_HUMAN; Nuclear factor RIP 140; Nuclear factor RIP140; Nuclear receptor interacting protein 1; Nuclear receptor-interacting protein 1; Receptor interacting protein 140; Receptor-interacting protein 140; RIP 140; RIP140
Target Background
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor.
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