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The antibody against NSFL1C was raised in rabbit using the Recombinant Human NSFL1 cofactor p47 protein (1-185AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against NSFL1C was raised in rabbit using the Recombinant Human NSFL1 cofactor p47 protein (1-185AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using NSFL1C Antibody at dilution of 1:1002
| Cat.No | ADC-17387A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NSFL1C |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human NSFL1 cofactor p47 protein (1-185AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UNZ2 |
Uniprot Id
Q9UNZ2
Target Species
Human
Target Name
NSFL1C
Target Full Name
NSFL1 cofactor p47
Target Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Target Subcellular Location
Nucleus. Golgi apparatus, Golgi stack. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families
NSFL1C family
Target Synonyms
DJ776F14.1; MGC3347; NSF1C_HUMAN; NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; NSFL1C; OTTHUMP00000029972; OTTHUMP00000029974; p47; P47 protein ; p97 cofactor p47; SHP1 homolog ; UBX domain protein 2C ; UBX domain-containing protein 2C; UBX1; UBXD10; UBXN2C
Target Background
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.
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