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The antibody against NSMF was raised in rabbit using the Recombinant Human NMDA receptor synaptonuclear signaling and neuronal migration factor protein (251-530AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against NSMF was raised in rabbit using the Recombinant Human NMDA receptor synaptonuclear signaling and neuronal migration factor protein (251-530AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human brain tissue using NSMF Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using NSMF Antibody at dilution of 1:1002
| Cat.No | ADC-16228A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NSMF |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human NMDA receptor synaptonuclear signaling and neuronal migration factor protein (251-530AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6X4W1 |
Uniprot Id
Q6X4W1
Target Species
Human
Target Name
NSMF
Target Full Name
NMDA receptor synaptonuclear signaling and neuronal migration factor
Target Function
Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
Target Involvement
Hypogonadotropic hypogonadism 9 with or without anosmia (HH9)
Target Subcellular Location
Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Membrane.
Target Protein Families
NSMF family
Target Tissue Specificity
Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney.
Target Synonyms
Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone releasing hormone factor; Nasal embryonic luteinizing hormone-releasing hormone factor; Nelf; NELF_HUMAN
Target Background
The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene.
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