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The antibody against NTN1 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Netrin-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against NTN1 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Netrin-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
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Western Blot analysis of COS7 cells using Netrin-1 Polyclonal Antibody
Western Blot analysis of 293 K562 COS cells using Netrin-1 Polyclonal Antibody2
| Cat.No | ADC-38115A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NTN1 |
| Target Synonyms | epididymis tissue protein Li 131P antibody; NET1_HUMAN antibody; Netrin 1, homolog of antibody; Netrin 1-like antibody; Netrin-1 antibody; Netrin1 antibody; Ntn 1 antibody; NTN 1L antibody; NTN1 antibody; NTN1L antibody; Unc6 antibody, mouse | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat, Monkey | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human Netrin-1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95631 |
Uniprot Id
O95631
Target Species
Human
Target Name
NTN1
Target Full Name
Netrin-1
Target Function
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Target Subcellular Location
Secreted. Cytoplasm.
Target Tissue Specificity
Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).
Target Synonyms
epididymis tissue protein Li 131P; NET1_HUMAN; Netrin 1, mouse, homolog of; Netrin 1-like; Netrin-1; Netrin1; Ntn 1; NTN 1L; NTN1; NTN1L; Unc6
Target Background
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.
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