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The antibody against NUCB2 was raised in rabbit using the Recombinant Human Nucleobindin-2 protein (25-106AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against NUCB2 was raised in rabbit using the Recombinant Human Nucleobindin-2 protein (25-106AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-10960A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Nucb2 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Nucleobindin-2 protein (25-106AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P80303 |
Uniprot Id
P80303
Target Species
Human
Target Name
NUCB2
Target Full Name
Nucleobindin-2
Target Function
Calcium-binding protein which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.; Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.
Target Subcellular Location
Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic reticulum. Nucleus envelope. Note=Golgi retention is mediated by its N-terminal region.; [Nesfatin-1]: Secreted.
Target Protein Families
Nucleobindin family
Target Tissue Specificity
Predominantly expressed in spleen, testis and normal stomach.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
DNA binding protein NEFA; DNA-binding protein NEFA; Gastric cancer antigen Zg4; HEL S 109; NEFA; Nefastin 1; Nefastin-1; Nefastin1; Nucb2; NUCB2_HUMAN; Nucleobindin 2; Nucleobindin-2; Nucleobinding 2; Prepronefastin; Prepronesfatin
Target Background
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains.
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