Rabbit anti-Human NUP133 Polyclonal Antibody

Uniprot Id

Q8WUM0

Target Species

Human

Target Name

NUP133

Target Full Name

Nuclear pore complex protein Nup133

Target Function

Involved in poly(A)+ RNA transport. Involved in nephrogenesis.

Target Subcellular Location

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore.

Target Protein Families

Nucleoporin Nup133 family

Target Tissue Specificity

Widely expressed in fetal and adult tissues. Expressed in the brain and kidney.

Target Synonyms

133 kDa nucleoporin; FLJ10814; hNUP 133; hNUP133; MGC21133; NU133_HUMAN; Nuclear pore complex protein Nup133; Nucleoporin 133kDa; Nucleoporin NUP133; NUP 133; NUP133; OTTHUMP00000061095

Target Background

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.