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The antibody against ODC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ODC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09932A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ODC1 |
| Target Synonyms | ODC; BABS; NEDBA; NEDBIA; ODC1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, 293T, HepG2, Raji, Rat kidney | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P11926 | Immunogen Sequence |
Uniprot Id
P11926
Target Species
Human
Target Name
ODC1
Target Full Name
Ornithine decarboxylase
Target Function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Target Protein Families
Orn/Lys/Arg decarboxylase class-II family
Target Research Area
Signal Transduction
Target Synonyms
DCOR_HUMAN; Dodc1; Odc 1; ODC; Odc1; ODC2; Ornithine decarboxylase 1; Ornithine decarboxylase 2; Ornithine decarboxylase; Ornithine decarboxylase structural 1; RNODC
Target Background
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
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