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The antibody against OGDHL was raised in rabbit using the Human OGDHL as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against OGDHL was raised in rabbit using the Human OGDHL as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-47746A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OGDHL |
| Target Synonyms | 2-oxoglutarate dehydrogenase complex component E1-like antibody; 2-oxoglutarate dehydrogenase-like, mitochondrial antibody; Alpha-ketoglutarate dehydrogenase-like antibody; KIAA1290 antibody; OGDC-E1-like antibody; OGDHL antibody; OGDHL_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human OGDHL | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9ULD0 |
Uniprot Id
Q9ULD0
Target Species
Human
Target Name
OGDHL
Target Full Name
2-oxoglutarate dehydrogenase-like, mitochondrial
Target Function
2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH. The OGDHC complex is mainly active in the mitochondrion. Involved in the inhibition of cell proliferation and in apoptosis.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Alpha-ketoglutarate dehydrogenase family
Target Tissue Specificity
Expressed in the brain and the liver.
Target Synonyms
2-oxoglutarate dehydrogenase complex component E1-like; 2-oxoglutarate dehydrogenase-like, mitochondrial; Alpha-ketoglutarate dehydrogenase-like; KIAA1290; OGDC-E1-like; OGDHL; OGDHL_HUMAN
Target Background
The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells.
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