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The antibody against OLFM4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 211-510 of human OLFM4 (NP_006409.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against OLFM4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 211-510 of human OLFM4 (NP_006409.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05097A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OLFM4 |
| Target Synonyms | GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1; OLFM4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse spleen, Mouse stomach, PC-3, Rat stomach | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 211-510 of human OLFM4 (NP_006409.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6UX06 | Immunogen Sequence |
Uniprot Id
Q6UX06
Target Species
Human
Target Name
OLFM4
Target Full Name
Olfactomedin-4
Target Function
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Target Subcellular Location
Secreted, extracellular space. Mitochondrion.
Target Tissue Specificity
Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone mar
Target Synonyms
Antiapoptotic protein GW112; bA209J19.1; G-CSF-stimulated clone 1 protein; GC1; GW112; hGC 1; hGC-1; hOLfD; KIAA4294; olfactomedin 4; Olfactomedin-4; OlfD; OLFM4; OLFM4_HUMAN; OLM4; UNQ362
Target Background
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion.
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