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The antibody against OPHN1 was raised in rabbit using the Recombinant Human Oligophrenin-1 protein (1-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against OPHN1 was raised in rabbit using the Recombinant Human Oligophrenin-1 protein (1-270AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using OPHN1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using OPHN1 Antibody at dilution of 1:1002
| Cat.No | ADC-17433A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OPHN1 |
| Target Synonyms | OPHN1 antibody; Oligophrenin-1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Oligophrenin-1 protein (1-270AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O60890 |
Uniprot Id
O60890
Target Species
Human
Target Name
OPHN1
Target Full Name
Oligophrenin-1
Target Function
Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.
Target Involvement
Mental retardation, X-linked, syndromic, OPHN1-related (MRXSO)
Target Subcellular Location
Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm.
Target Tissue Specificity
Expressed in brain.
Target Synonyms
OPHN1; Oligophrenin-1
Target Background
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism.
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