Rabbit anti-Human OSGEP Polyclonal Antibody

The antibody against OSGEP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human OSGEP (NP_060277.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02488A

Number

Cat.No	ADA-02488A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	OSGEP
Target Synonyms	KAE1; TCS3; GCPL1; GAMOS3; OSGEP1; PRSMG1; OSGEP	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Rat heart, 293T, HL-60, Jurkat, Mouse ovary, Mouse skeletal muscle, Raji, Rat liver	Application	ELISA, WB

Cat.No

ADA-02488A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

OSGEP

Target Synonyms

KAE1; TCS3; GCPL1; GAMOS3; OSGEP1; PRSMG1; OSGEP

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Rat heart, 293T, HL-60, Jurkat, Mouse ovary, Mouse skeletal muscle, Raji, Rat liver

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human OSGEP (NP_060277.1).	Target Species	Human
Uniprot ID	Q9NPF4	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human OSGEP (NP_060277.1).

Target Species

Human

Uniprot ID

Q9NPF4

Immunogen Sequence

Background Information

Uniprot Id

Q9NPF4
Target Species

Human
Target Name

OSGEP
Target Full Name

tRNA N6-adenosine threonylcarbamoyltransferase
Target Function

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

KAE1 / TsaD family
Target Tissue Specificity

Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.
Target Research Area

others
Target Synonyms

FLJ20411; GCPL-1; GCPL1; hOSGEP; KAE1; O sialoglycoprotein endopeptidase; OSGEP; OSGEP_HUMAN; OSGEP1; Pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1; Probable O sialoglycoprotein endopeptidase; Probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep; PRSMG1; Prsmg1/Gcpl1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep
Target Background

Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3.

Rabbit anti-Human OSGEP Polyclonal Antibody

Specifications

Immunogen Information

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