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The antibody against OTC was raised in rabbit using the Recombinant Human Ornithine carbamoyltransferase, mitochondrial protein (33-354AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against OTC was raised in rabbit using the Recombinant Human Ornithine carbamoyltransferase, mitochondrial protein (33-354AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-44646A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OTC |
| Target Synonyms | mitochondrial antibody; Ornithine transcarbamylase antibody; Otc antibody; OTC_HUMAN antibody; OTCase antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ornithine carbamoyltransferase, mitochondrial protein (33-354AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P00480 |
Uniprot Id
P00480
Target Species
Human
Target Name
OTC
Target Full Name
Ornithine transcarbamylase, mitochondrial
Target Function
Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
Target Involvement
Ornithine carbamoyltransferase deficiency (OTCD)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
ATCase/OTCase family
Target Tissue Specificity
Mainly expressed in liver and intestinal mucosa.
Target Synonyms
EC 2.1.3.3; MGC129967; MGC129968; MGC138856; OCTD; Ornithine Carbamoyltransferase; Ornithine carbamoyltransferase mitochondrial; Ornithine carbamoyltransferase, mitochondrial; Ornithine transcarbamylase; Otc; OTC_HUMAN; OTCase
Target Background
This nuclear gene encodes a mitochondrial matrix enzyme. The encoded protein is involved in the urea cycle which functions to detoxify ammonia into urea for excretion. Mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia.
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