Rabbit anti-Human OVOL2 Polyclonal Antibody

Uniprot Id

Q9BRP0

Target Species

Human

Target Name

OVOL2

Target Full Name

Transcription factor Ovo-like 2

Target Function

Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos.

Target Involvement

Corneal dystrophy, posterior polymorphous, 1 (PPCD1)

Target Subcellular Location

Nucleus.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family

Target Tissue Specificity

Expressed in testis, ovary, heart and skeletal muscle. Expressed in the cornea, but absent from the corneal endothelium.

Target Synonyms

bA504H3.3; EUROIMAGE566589; hOvo 2; hOvo2; Ovo like 2 (Drosophila); Ovo like 2; ovo-like zinc finger 2; OVOL 2; OVOL2; OVOL2_HUMAN; Transcription factor Ovo like 2; Transcription factor Ovo-like 2; Zinc finger protein 339; ZNF 339; ZNF339

Target Background

This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy.