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The antibody against OXCT1 was raised in rabbit using the Recombinant Human Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial protein (40-520AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against OXCT1 was raised in rabbit using the Recombinant Human Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial protein (40-520AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-49990A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OXCT1 |
| Target Synonyms | mitochondrial antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial protein (40-520AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P55809 |
Uniprot Id
P55809
Target Species
Human
Target Name
OXCT1
Target Full Name
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Target Function
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Target Involvement
Succinyl-CoA:3-oxoacid CoA transferase deficiency (SCOTD)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
3-oxoacid CoA-transferase family
Target Tissue Specificity
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
Target Research Area
Cancer
Target Synonyms
3 oxoacid CoA transferase 1; 3-oxoacid CoA-transferase 1; EC 2.8.3.5; OTTHUMP00000120012; OTTHUMP00000221550; OXCT; Oxct1; SCOT; Scot S; Scot-S; SCOT1_HUMAN; Somatic type succinyl CoA:3 oxoacid CoA transferase; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Succinyl CoA:3 ketoacid CoA transferase; Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial; Succinyl CoA:3 oxoacid CoA transferase; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Target Background
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.
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