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The antibody against P4HA1 was raised in rabbit using the Recombinant Human Prolyl 4-hydroxylase subunit alpha-1 protein (256-525AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against P4HA1 was raised in rabbit using the Recombinant Human Prolyl 4-hydroxylase subunit alpha-1 protein (256-525AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human skin tissue using P4HA1 Antibody at dilution of 1:1002
| Cat.No | ADC-12534A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | P4HA1 |
| Target Synonyms | 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), 2-oxoglutarate-4-dioxygenase subunit alpha-1 antibody; 4-hydroxylase, alpha I subunit antibody; 4-PH alpha-1 antibody; P4HA antibody; P4HA1 antibody; P4HA1_HUMAN antibody; Procollagen-proline antibody; Procollagen-proline, alpha polypeptide I antibody; Prolyl 4-hydroxylase subunit alpha-1 antibody | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Prolyl 4-hydroxylase subunit alpha-1 protein (256-525AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P13674 |
Uniprot Id
P13674
Target Species
Human
Target Name
P4HA1
Target Full Name
Prolyl 4-hydroxylase subunit alpha-1
Target Function
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Target Subcellular Location
Endoplasmic reticulum lumen.
Target Protein Families
P4HA family
Target Research Area
Signal Transduction
Target Synonyms
2-oxoglutarate-4-dioxygenase subunit alpha-1; 4-hydroxylase, alpha I subunit; 4-PH alpha-1; P4HA; P4HA1; P4HA1_HUMAN; Procollagen-proline; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; Prolyl 4-hydroxylase subunit alpha-1
Target Background
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
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