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The antibody against PACSIN3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 175-424 of human PACSIN3 (NP_057307.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PACSIN3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 175-424 of human PACSIN3 (NP_057307.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01140A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PACSIN3 |
| Target Synonyms | SDPIII; PACSIN3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Rat brain, HepG2, Jurkat, MCF7, Mouse liver, Mouse lung, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 175-424 of human PACSIN3 (NP_057307.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UKS6 | Immunogen Sequence |
Uniprot Id
Q9UKS6
Target Species
Human
Target Name
PACSIN3
Target Full Name
Protein kinase C and casein kinase substrate in neurons protein 3
Target Function
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
Target Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
PACSIN family
Target Tissue Specificity
Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.
Target Synonyms
Endophilin 1; Endophilin I; FLJ17861; OTTHUMP00000234262; OTTHUMP00000234263; OTTHUMP00000234264; PACN3_HUMAN; Pacsin3; Protein kinase C and casein kinase substrate in neurons 3; Protein kinase C and casein kinase substrate in neurons protein 3; SDPIII; SH3 domain containing protein 6511; SH3 domain-containing protein 6511; syndapin III
Target Background
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants.
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