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The antibody against PADI1 was raised in rabbit using the Recombinant Human Protein-arginine deiminase type-1 protein (1-663AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against PADI1 was raised in rabbit using the Recombinant Human Protein-arginine deiminase type-1 protein (1-663AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-17777A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PADI1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein-arginine deiminase type-1 protein (1-663AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9ULC6 |
Uniprot Id
Q9ULC6
Target Species
Human
Target Name
PADI1
Target Full Name
Protein-arginine deiminase type-1
Target Function
Catalyzes the deimination of arginine residues of proteins.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Protein arginine deiminase family
Target Tissue Specificity
Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
HPAD10; Padi1; PADI1_HUMAN; PDI; PDI1; Peptidylarginine deiminase I; protein arginine deiminase type I; Protein-arginine deiminase type I; Protein-arginine deiminase type-1
Target Background
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.
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