Rabbit anti-Human PADI2 Polyclonal Antibody

Uniprot Id

Q9Y2J8

Target Species

Human

Target Name

PADI2

Target Full Name

Protein-arginine deiminase type-2

Target Function

Catalyzes the deimination of arginine residues of proteins.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein arginine deiminase family

Target Tissue Specificity

Detected in keratinocytes in epidermis (at protein level).

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

KIAA0994; OTTHUMP00000044625; PAD 2; PAD H19 ; PAD-H19; PAD2; PADI 2; Padi2; PADI2 protein; PADI2_HUMAN; PDI 2; PDI2; Peptidlyarginine deiminase type II; Peptidyl arginine deiminase II; Peptidyl arginine deiminase type II; Peptidylarginine deiminase II; Protein arginine deiminase; Protein arginine deiminase type 2; Protein arginine deiminase type II; Protein-arginine deiminase type II; Protein-arginine deiminase type-2

Target Background

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.