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The antibody against PAFAH1B2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human PAFAH1B2 (NP_002563.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PAFAH1B2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human PAFAH1B2 (NP_002563.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09268A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAFAH1B2 |
| Target Synonyms | HEL-S-303; PAFAH1B2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, LO2, Mouse brain, Mouse testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human PAFAH1B2 (NP_002563.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P68402 | Immunogen Sequence |
Uniprot Id
P68402
Target Species
Human
Target Name
PAFAH1B2
Target Full Name
Platelet-activating factor acetylhydrolase IB subunit alpha2
Target Function
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.
Target Subcellular Location
Cytoplasm.
Target Protein Families
'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Intracellular platelet activating factor acetylhydrolase alpha 2 subunit; PA1B2_HUMAN; PAF acetylhydrolase 30 kDa subunit; PAF AH 30 kDa subunit; PAF AH beta subunit; PAF AH subunit beta; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH 30 kDa subunit; PAFAH beta subunit; PAFAH subunit beta; Pafah1b2; PAFAH1B2 protein; PAFAHB; Platelet activating factor acetylhydrolase 1b catalytic subunit 2; Platelet activating factor acetylhydrolase IB beta subunit ; Platelet activating factor acetylhydrolase IB subunit beta; Platelet activating factor acetylhydrolase isoform Ib beta subunit ; Platelet activating factor acetylhydrolase isoform Ib subunit 2; Platelet-activating factor acetylhydrolase IB subunit beta
Target Background
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene.
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