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The antibody against PAFAH1B2 was raised in rabbit using the Recombinant Human Platelet-activating factor acetylhydrolase IB subunit beta protein (2-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PAFAH1B2 was raised in rabbit using the Recombinant Human Platelet-activating factor acetylhydrolase IB subunit beta protein (2-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunofluorescent analysis of MCF-7 cells using PAFAH1B2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunohistochemistry analysis of human colon cancer using PAFAH1B2 Antibody at dilution of 1:1002
Immunohistochemistry analysis of human glioma using PAFAH1B2 Antibody at dilution of 1:1003
| Cat.No | ADC-24167A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAFAH1B2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Platelet-activating factor acetylhydrolase IB subunit beta protein (2-229AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P68402 |
Uniprot Id
P68402
Target Species
Human
Target Name
PAFAH1B2
Target Full Name
Platelet-activating factor acetylhydrolase IB subunit alpha2
Target Function
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.
Target Subcellular Location
Cytoplasm.
Target Protein Families
'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Intracellular platelet activating factor acetylhydrolase alpha 2 subunit; PA1B2_HUMAN; PAF acetylhydrolase 30 kDa subunit; PAF AH 30 kDa subunit; PAF AH beta subunit; PAF AH subunit beta; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH 30 kDa subunit; PAFAH beta subunit; PAFAH subunit beta; Pafah1b2; PAFAH1B2 protein; PAFAHB; Platelet activating factor acetylhydrolase 1b catalytic subunit 2; Platelet activating factor acetylhydrolase IB beta subunit ; Platelet activating factor acetylhydrolase IB subunit beta; Platelet activating factor acetylhydrolase isoform Ib beta subunit ; Platelet activating factor acetylhydrolase isoform Ib subunit 2; Platelet-activating factor acetylhydrolase IB subunit beta
Target Background
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene.
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