Rabbit anti-Human PAFAH1B2 Polyclonal Antibody

Uniprot Id

P68402

Target Species

Human

Target Name

PAFAH1B2

Target Full Name

Platelet-activating factor acetylhydrolase IB subunit alpha2

Target Function

Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.

Target Subcellular Location

Cytoplasm.

Target Protein Families

'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Intracellular platelet activating factor acetylhydrolase alpha 2 subunit; PA1B2_HUMAN; PAF acetylhydrolase 30 kDa subunit; PAF AH 30 kDa subunit; PAF AH beta subunit; PAF AH subunit beta; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH 30 kDa subunit; PAFAH beta subunit; PAFAH subunit beta; Pafah1b2; PAFAH1B2 protein; PAFAHB; Platelet activating factor acetylhydrolase 1b catalytic subunit 2; Platelet activating factor acetylhydrolase IB beta subunit ; Platelet activating factor acetylhydrolase IB subunit beta; Platelet activating factor acetylhydrolase isoform Ib beta subunit ; Platelet activating factor acetylhydrolase isoform Ib subunit 2; Platelet-activating factor acetylhydrolase IB subunit beta

Target Background

Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene.