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The antibody against E7 was raised in rabbit using the Recombinant Human papillomavirus type 18 Protein E7 protein (1-105AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against E7 was raised in rabbit using the Recombinant Human papillomavirus type 18 Protein E7 protein (1-105AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49723A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | E7 |
| Target Synonyms | E7Protein E7 antibody | Form | Liquid |
| Species Reactivity | Human papillomavirus type 18 | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human papillomavirus type 18 Protein E7 protein (1-105AA) | Target Species | Human papillomavirus type 18 |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P06788 |
Uniprot Id
P06788
Target Species
Human papillomavirus type 18
Target Name
E7
Target Function
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
Target Subcellular Location
Host cytoplasm. Host nucleus.
Target Protein Families
Papillomaviridae E7 protein family
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