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The antibody against PARL was raised in rabbit using the Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial protein (1-170AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against PARL was raised in rabbit using the Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial protein (1-170AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human kidney tissue using PARL Antibody at dilution of 1:100
| Cat.No | ADC-40447A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PARL |
| Target Synonyms | mitochondrial; Mitochondrial intramembrane cleaving protease PARL, PARL; PSARL; PRO2207; Presenilins-associated rhomboid-like protein | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial protein (1-170AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H300 |
Uniprot Id
Q9H300
Target Species
Human
Target Name
PARL
Target Full Name
Presenilin-associated rhomboid-like protein, mitochondrial
Target Function
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.; [P-beta]: Nucleus.
Target Protein Families
Peptidase S54 family
Target Synonyms
PARL; PSARL; PRO2207; Presenilins-associated rhomboid-like protein, mitochondrial; Mitochondrial intramembrane cleaving protease PARL
Target Background
This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease.
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