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The antibody against NS1 was raised in rabbit using the Recombinant Human parvovirus B19 Non-capsid protein NS-1 protein (1-255AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against NS1 was raised in rabbit using the Recombinant Human parvovirus B19 Non-capsid protein NS-1 protein (1-255AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-02581A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NS1 |
| Form | Liquid | Species Reactivity | Human parvovirus B19 |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human parvovirus B19 Non-capsid protein NS-1 protein (1-255AA) | Target Species | Human parvovirus B19 |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P07298 |
Uniprot Id
P07298
Target Species
Human parvovirus B19
Target Name
NS1
Target Function
Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins. Upregulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition. This arrest promotes apoptosis for viral release.
Target Subcellular Location
Host nucleus.
Target Protein Families
Parvoviruses non-capsid protein family
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