Rabbit anti-Human PBR/TSPO Monoclonal Antibody

The antibody against PBR/TSPO was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 70-169 of human PBR/TSPO (P30536) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-16794A

Number

Cat.No	ADA-16794A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	PBR/TSPO
Target Synonyms	DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18; TSPO1; PBR/TSPO	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, Mouse liver, Mouse lung, Mouse spleen	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-16794A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

PBR/TSPO

Target Synonyms

DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18; TSPO1; PBR/TSPO

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, Mouse liver, Mouse lung, Mouse spleen

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 70-169 of human PBR/TSPO (P30536).	Target Species	Human
Immunogen Sequence	ELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE	Uniprot ID	P30536

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 70-169 of human PBR/TSPO (P30536).

Target Species

Human

Immunogen Sequence

ELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

Uniprot ID

P30536

Background Information

Uniprot Id

P30536
Target Species

Human
Target Name

TSPO
Target Full Name

Translocator protein
Target Function

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.
Target Subcellular Location

Mitochondrion membrane; Multi-pass membrane protein.
Target Protein Families

TspO/BZRP family
Target Tissue Specificity

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
Target Synonyms

TSPO; BZRP; MBR; Translocator protein; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
Target Background

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.

Rabbit anti-Human PBR/TSPO Monoclonal Antibody

Specifications

Immunogen Information

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