Rabbit anti-Human PCDHA12 Polyclonal Antibody

Uniprot Id

Q9UN75

Target Species

Human

Target Name

PCDHA12

Target Full Name

Protocadherin alpha-12

Target Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Synonyms

KIAA0345 like 2; MGC138485; MGC141932; PCDAC_HUMAN; PCDH alpha 12; PCDH alpha12; PCDH-alpha-12; PCDHA12; Protocadherin alpha 12; Protocadherin alpha-12

Target Background

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.