Rabbit anti-Human PCGF6 Polyclonal Antibody

The antibody against PCGF6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 161-350 of human PCGF6 (NP_001011663.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03681A

Number

Cat.No	ADA-03681A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PCGF6
Target Synonyms	MBLR; RNF134; PCGF6	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	MCF7	Application	ELISA, WB

Cat.No

ADA-03681A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PCGF6

Target Synonyms

MBLR; RNF134; PCGF6

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

MCF7

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 161-350 of human PCGF6 (NP_001011663.1).	Target Species	Human
Immunogen Sequence	RHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT	Uniprot ID	Q9BYE7

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 161-350 of human PCGF6 (NP_001011663.1).

Target Species

Human

Immunogen Sequence

RHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT

Uniprot ID

Q9BYE7

Background Information

Uniprot Id

Q9BYE7
Target Species

Human
Target Name

PCGF6
Target Full Name

Polycomb group RING finger protein 6
Target Function

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Ubiquitous.
Target Synonyms

MBLR; Mel18 and Bmi1 like RING finger protein; Mel18 and Bmi1-like RING finger; Pcgf6; PCGF6_HUMAN; Polycomb group RING finger protein 6; RING finger protein 134; RNF134
Target Background

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Rabbit anti-Human PCGF6 Polyclonal Antibody

Specifications

Immunogen Information

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