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The antibody against PCGF6 was raised in rabbit using the Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against PCGF6 was raised in rabbit using the Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-03831A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PCGF6 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BYE7 |
Uniprot Id
Q9BYE7
Target Species
Human
Target Name
PCGF6
Target Full Name
Polycomb group RING finger protein 6
Target Function
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
MBLR; Mel18 and Bmi1 like RING finger protein; Mel18 and Bmi1-like RING finger; Pcgf6; PCGF6_HUMAN; Polycomb group RING finger protein 6; RING finger protein 134; RNF134
Target Background
The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.
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