Rabbit anti-Human PDE10A Polyclonal Antibody

Uniprot Id

Q9Y233

Target Species

Human

Target Name

PDE10A

Target Full Name

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Target Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.

Target Involvement

Dyskinesia, limb and orofacial, infantile-onset (IOLOD); Striatal degeneration, autosomal dominant 2 (ADSD2)

Target Subcellular Location

Cytoplasm. Note=Located mostly to soluble cellular fractions.

Target Protein Families

Cyclic nucleotide phosphodiesterase family

Target Tissue Specificity

Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.

Target Synonyms

ADSD2; IOLOD; HSPDE10A; PDE10A19; LINC00473; PDE10A

Target Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.