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The antibody against PDE12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PDE12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02083A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE12 |
| Target Synonyms | 2-PDE; 2'-PDE; PDE12 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse thymus, Rat thymus | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6L8Q7 | Immunogen Sequence |
Uniprot Id
Q6L8Q7
Target Species
Human
Target Name
PDE12
Target Full Name
2',5'-phosphodiesterase 12
Target Function
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
CCR4/nocturin family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
2 PDE; 2' 5' phosphodiesterase 12; 2' phosphodiesterase; 2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 2PDE; DKFZp667B1218; Pde12; PDE12_HUMAN; Phosphodiesterase 12
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