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The antibody against PDE2A was raised in rabbit using the Recombinant Human cGMP-dependent 3\',5\'-cyclic phosphodiesterase protein (15-226AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against PDE2A was raised in rabbit using the Recombinant Human cGMP-dependent 3\’,5\’-cyclic phosphodiesterase protein (15-226AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human kidney tissue using PDE2A Antibody at dilution of 1:1002
| Cat.No | ADC-12529A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE2A |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human cGMP-dependent 3',5'-cyclic phosphodiesterase protein (15-226AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O00408 |
Uniprot Id
O00408
Target Species
Human
Target Name
PDE2A
Target Full Name
cGMP-dependent 3',5'-cyclic phosphodiesterase
Target Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line).; Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Target Subcellular Location
[Isoform PDE2A3]: Cell membrane; Lipid-anchor.; [Isoform PDE2A2]: Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane.; [Isoform PDE2A1]: Cytoplasm.; [Isoform 5]: Mitochondrion.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE2 subfamily
Target Tissue Specificity
Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Target Synonyms
5''-cyclic phosphodiesterase; cGMP dependent 3'5' cyclic phosphodiesterase; cGMP stimulated phosphodiesterase 1; cGMP stimulated phosphodiesterase 4; cGMP-dependent 3''; cGMP-stimulated phosphodiesterase 2; CGS PDE; CGS-PDE; cGSPDE; Cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase; PDE 2A; PDE 2A1; PDE 2A4; PDE2A; PDE2A_HUMAN; PDE2A1; PDE2A4; phosphodiesterase 2A; Phosphodiesterase 2A cGMP stimulated
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