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The antibody against PDE4D was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 249-518 of human PDE4D (NP_001184152.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PDE4D was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 249-518 of human PDE4D (NP_001184152.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05931A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE4D |
| Target Synonyms | DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; PDE4D | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, HT-29, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 249-518 of human PDE4D (NP_001184152.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q08499 | Immunogen Sequence |
Uniprot Id
Q08499
Target Species
Human
Target Name
PDE4D
Target Full Name
3',5'-cyclic-AMP phosphodiesterase 4D
Target Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Target Involvement
Acrodysostosis 2, with or without hormone resistance (ACRDYS2)
Target Subcellular Location
Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
Target Tissue Specificity
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Target Synonyms
DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; PDE4D
Target Background
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3', 5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
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