Rabbit anti-Human PDE5A Polyclonal Antibody

The antibody against PDE5A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDE5A (NP_001074.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02828A

Number

Cat.No	ADA-02828A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PDE5A
Target Synonyms	CN5A; PDE5; CGB-PDE; PDE5A	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	22Rv1, A-549, HT-1080, Mouse brain, Mouse skeletal muscle, Rat skeletal muscle, SKOV3	Application	ELISA, WB

Cat.No

ADA-02828A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PDE5A

Target Synonyms

CN5A; PDE5; CGB-PDE; PDE5A

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

22Rv1, A-549, HT-1080, Mouse brain, Mouse skeletal muscle, Rat skeletal muscle, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDE5A (NP_001074.2).	Target Species	Human
Immunogen Sequence	MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCS	Uniprot ID	O76074

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDE5A (NP_001074.2).

Target Species

Human

Immunogen Sequence

MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCS

Uniprot ID

O76074

Background Information

Uniprot Id

O76074
Target Species

Human
Target Name

PDE5A
Target Full Name

cGMP-specific 3',5'-cyclic phosphodiesterase
Target Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Target Protein Families

Cyclic nucleotide phosphodiesterase family
Target Tissue Specificity

Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
Target Synonyms

5''-cyclic phosphodiesterase; CGB PDE; CGB-PDE; CGBPDE; cGMP binding cGMP specific 3' 5' cyclic nucleotide phosphodiesterase; cGMP binding cGMP specific 35 cyclic nucleotide phosphodiesterase ; cGMP binding cGMP specific phosphodiesterase; cGMP binding/cGMP specific phosphodiesterase ; cGMP specific 3'5' cyclic phosphodiesterase ; cGMP specific phosphodiesterase PDE5A2; cGMP specific phosphodiesterase type 5A; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3''; CN5A; CN5N; PDE 5; PDE 5A; PDE5; Pde5a; PDE5A_HUMAN; PDE5A1; Phosphodiesterase 5A; Phosphodiesterase 5A cGMP specific; Phosphodiesterase isozyme 5
Target Background

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

Rabbit anti-Human PDE5A Polyclonal Antibody

Specifications

Immunogen Information

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