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The antibody against PDE6A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 656-860 of human PDE6A (NP_000431.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PDE6A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 656-860 of human PDE6A (NP_000431.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01875A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE6A |
| Target Synonyms | PDEA; RP43; CGPR-A; PDE6A | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, BT-474 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 656-860 of human PDE6A (NP_000431.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P16499 | Immunogen Sequence |
Uniprot Id
P16499
Target Species
Human
Target Name
PDE6A
Target Full Name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Target Function
This protein participates in processes of transmission and amplification of the visual signal.
Target Involvement
Retinitis pigmentosa 43 (RP43)
Target Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side.
Target Protein Families
Cyclic nucleotide phosphodiesterase family
Target Synonyms
PDEA; RP43; CGPR-A; PDE6A
Target Background
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
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