Rabbit anti-Human PDE6B Polyclonal Antibody

Uniprot Id

P35913

Target Species

Human

Target Name

PDE6B

Target Full Name

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Target Function

Necessary for the formation of a functional phosphodiesterase holoenzyme. Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock. May participate in processes of transmission and amplification of the visual signal.

Target Involvement

Retinitis pigmentosa 40 (RP40); Night blindness, congenital stationary, autosomal dominant 2 (CSNBAD2)

Target Subcellular Location

Membrane; Lipid-anchor.

Target Protein Families

Cyclic nucleotide phosphodiesterase family

Target Synonyms

rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta; PDE6B

Target Background

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.