Rabbit anti-Human PDHB Monoclonal Antibody

The antibody against PDHB was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 260-359 of human Pyruvate Dehydrogenase E1 beta subunit (P11177) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-16793A

Number

Cat.No	ADA-16793A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	PDHB
Target Synonyms	PDHBD; PHE1B; E1beta; PDHE1B; PDHE1-B; PDHB	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Rat heart, 293T, K-562, Mouse liver, Mouse skeletal muscle, Rat kidney, Rat skeletal muscle, U-251MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-16793A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

PDHB

Target Synonyms

PDHBD; PHE1B; E1beta; PDHE1B; PDHE1-B; PDHB

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Rat heart, 293T, K-562, Mouse liver, Mouse skeletal muscle, Rat kidney, Rat skeletal muscle, U-251MG

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 260-359 of human Pyruvate Dehydrogenase E1 beta subunit (P11177).	Target Species	Human
Immunogen Sequence	GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI	Uniprot ID	P11177

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 260-359 of human Pyruvate Dehydrogenase E1 beta subunit (P11177).

Target Species

Human

Immunogen Sequence

GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI

Uniprot ID

P11177

Background Information

Uniprot Id

P11177
Target Species

Human
Target Name

PDHB
Target Full Name

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Target Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Target Involvement

Pyruvate dehydrogenase E1-beta deficiency (PDHBD)
Target Subcellular Location

Mitochondrion matrix.
Target Research Area

Cancer
Target Synonyms

DKFZp564K0164; mitochondrial; ODPB_HUMAN; pdhB; PDHBD; PDHE1 B; PDHE1-B; PHE1B; Pyruvate dehydrogenase (lipoamide) beta; Pyruvate dehydrogenase E1 beta polypeptide; Pyruvate dehydrogenase E1 component subunit beta; Pyruvate dehydrogenase E1 component subunit beta mitochondrial
Target Background

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene.

Rabbit anti-Human PDHB Monoclonal Antibody

Specifications

Immunogen Information

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