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The antibody against PDZRN3 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PDZRN3 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human gastric cancer using PDZRN3 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using PDZRN3 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-14137A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDZRN3 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPQ7 |
Uniprot Id
Q9UPQ7
Target Species
Human
Target Name
PDZRN3
Target Full Name
E3 ubiquitin-protein ligase PDZRN3
Target Function
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
Target Subcellular Location
Cell junction, synapse. Cytoplasm.
Target Tissue Specificity
Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
Target Synonyms
E3 ubiquitin-protein ligase PDZRN3; KIAA1095; Ligand of Numb protein X 3; likely ortholog of mouse semaF cytoplasmic domain associated protein 3; LNX3; PDZ domain containing ring finger 3 ; PDZ domain-containing RING finger protein 3; Pdzrn3; Protein SEMACAP3; PZRN3_HUMAN; SEMACAP3; Semaphorin cytoplasmic domain associated protein ; Semaphorin cytoplasmic domain-associated protein 3; SEMCAP3
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